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Celiac Disease “Journal Club” 2013 Part 2

This is going to be a quick post, as I am getting ready to head to Cincinnati for a wedding, and then to Chicago for the International Celiac Disease Symposium 9/22-9/25. I look forward to being able to meet some of you in person at this conference, and to hear the experts, including Dr. Fasano, speak about the most recent research, recommendations, and guidelines regarding the diagnosis and management of both celiac disease and non-celiac gluten sensitivity.

Below are summaries of three recent journal articles that may be of interest. Part 1 of my Celiac “Journal Club” series can be seen here. Under each article summary statement I am including a link to some of my previous posts about relevant topics.

1. “2013 update on celiac disease and eosinophilic esophagitis.” Authors: Pellicano, R, et al. Published in Nutrients in Aug. 2013.

-authors reviewed 30 publications regarding celiac disease and eosinophilic esophagitis (EoE), a chronic inflammatory disorder of the esophagus which is on the rise. They found that the prevalence of EoE in subjects with celiac disease is 10x higher than the general population in the majority of the studies. They recommend that all children who get small intestinal biopsies for celiac disease diagnosis also get evaluated for EoE.

-for more information on the relationship between EoE and Celiac Disease, as well as an overview of the symptoms of EoE, please see my post from Jan. 2013.

2. “The rising incidence of celiac disease in Scotland.”  Authors: White, L, et al. Published in Pediatrics in Sept. 2013.

-researchers looked at the incidence of celiac disease in children in Scotland from 1990 to 2009. Overall incidence increased by 640% over this 20 year period, with the incidence of “atypical” celiac disease increasing by 1140%!

-of note, 51% of the children who were actively screened for celiac disease and found to have celiac disease had no symptoms at all. Active screening takes place if a child is in a “high risk” category for celiac disease, i.e. has a sibling or other first degree relative with celiac disease.

-for more information on the screening of children for celiac disease, and who should be screened, please check out my post from June 2013.

3. “Potential new mechanisms of placental damage in celiac disease: anti-tranglutaminase antibodies impair human endometrial angiogenesis.” Authors: Simone, N., et al. Published in Biol Reprod in Aug. 2013.

-the authors demonstrate that tissue transglutaminase antibodies seen in celiac disease damage the placenta by interfering with the development of crucial placental blood vessels.  This finding helps to explain why women with untreated celiac disease often have problems of infertility, miscarriages, and fetal growth restriction.

-I wrote about the topics of Celiac Disease and Pregnancy in Jan. 2013 (see link) and Celiac Disease and Infertility in Mar. 2013 (see link).

I anticipate returning from Chicago with a lot to write about on this page. I will also be making my conference tweeting debut (@PatientCeliac), so feel free to follow me for real-time updates. Lastly, if you will be attending, please reach out and let me know so that we can meet!

5 thoughts on “Celiac Disease “Journal Club” 2013 Part 2

  1. Rachael

    I really enjoy your breakdown of the recently published studies. “Dumbing it down” for folks like myself, is greatly appreciated! I will be attending the symposium as well. Two of my three children as well as myself, were diagnosed a little over two years ago and I’m so excited to attend and see if I can gain some insight into why our youngest daughter still has a high antibody count despite being strictly gluten free for two years. I hope to meet you. I really enjoy your blog.

    1. Jess Post author

      Hi Rachael,
      I am so happy to learn that you will be there too. I will keep an eye out for you. If you’d like to make definite plans to meet up, you can send me an email at thepatientceliac@gmail.com, or send me a message through FB.
      Safe travels to Chicago this weekend!
      Jess

  2. Vik

    Jess, I have never followed anybody’s twitter feed before. I followed yours, and two others, and you did a really great job! I’m so impressed that you were able to multitask listening to sessions, with doing the Twitter feed. Can’t wait to read a more expanded version of your conference experience. I’ll be especially watching for info that answers some of the questions I’ve had as I’ve gone further along the GF-dom trail. How did you do with the food situation at the conference?

    1. Jess Post author

      Hi Vik,
      The conference exceeded my expectations and I am so thankful that my local Celiac support group gave me a partial scholarship so that I could attend. All of the food (breakfast and lunch x 3 days plus dinner on Sunday night) was gluten free. It was the first time that I did not freak out about being exposed to crumbs while out in public. I just arrived home a while ago and have information overload, so I hope to collect my thoughts and start to write in the next few days. Also, just as an FYI, the next symposium will be in Prague in June of 2014. Also, if I am remembering correctly, the issue of bone mineral density was discussed several times, and the consensus is that there is improvement in bone density after GF, but it may not ever totally normalize (was this something you had asked at one point). I have a big old book of abstracts with authors, so once I can find some of the abstracts I will post info on here for you). Jess

      1. Vik

        Hi Jess, I am so glad you had a great and informative time. Even with the food. I seldom go out to eat, and really don’t enjoy it anymore since the celiac diagnosis, re crumbs and other cross contamination you mentioned. And thank you for sharing what these experts had to say….what with your 4 young kids and job, as well as your blog…so extra appreciated that you make time. There is so much conflicting info out on the web, and my HMO doesn’t seem to know a lot about the seriousness of celiac. Yes, bone density was one of the things I was wondering about. Do the abstracts have info about how we can improve it? I have to admit, sometimes reading these various studies can creep me out. I know how you love your journal club…I think–ok I know, I would succumb to hypochondria, as I tend towards the more anxious frame of mind, especially concerning medical issues :-)

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